Dr. Gautschi received his doctorate while studying marine natural products from sponge and deep-water, marine-derived fungal species from Papua New Guinea.  Dr. Gautschi then joined Bend Research Inc. as a research scientist working on drug discovery, drug delivery, and business development projects. He later helped start Agere Pharmaceuticals in 2009 as their first employee, becoming Director of Research and Development in 2011. Dr. Gautschi joined OSU in the fall of 2012.

Research/Career Interests

Dr. Gautschi’s research currently focuses on two aspects of drug discovery and development.  The first includes the search for bioactive and/or novel organic compounds from a genetically modified fungus, Fusarium graminearium, in collaboration with Drs. Michael Freitag (OSU) and Kristina Smith (OSU).  The second explores the non-sink in vitro dissolution testing of pharmaceutical substances, drug candidates, and/or therapeutic agents. Undergraduate students interested in participating in this research must first demonstrate proficiencies in organic chemistry and then contact Dr. Gautschi directly.

Teaching

Dr. Gautschi brings his natural product and pharmaceutical industry experiences to bear on teaching organic chemistry at OSU-Cascades. He also provides instruction for OSU Ecampus chemistry courses at OSU (Corvallis).  Dr. Gautschi established the organic chemistry series and teaching lab at OSU-Cascades in 2013, and will implement the general chemistry series (with labs), along with an environmental chemistry course, in 2014.

Representative Publications, Patents, and Speakerships

Gautschi, J. T. Chapter 8. Non-sink in vitro dissolution testing of amorphous solid dispersions. In M. A. Repka and J. DiNunzio (Eds.), Melt Extrusion. AAPS Advances in the Pharmaceutical Sciences Series 9. Springer, (in press).

Padval, M. V., Gautschi, J. T., Smithey, D. T., Crew, M. D., Harianawala, A. Solid dispersion formulations and methods of use thereof. US 8,409,560, issued: April 2, 2013.

Gautschi, J.T., Smithey, D.T., Choo, E., Afflerbaugh, L., Savage, S., Segraves, N., Grina, J., Rudolph, J., Ran, Y. Applying oral molecular dispersions to lead selection: a case study using a homologous series of solubility-limited compounds, American Association of Pharmaceutical Scientists Annual Meeting, November 2011, Poster W5231.

Smithey, D.T., Fennewald, J.C., Gautschi, J.T., Crew, M.D., Ali, S., Lan, Y., Langley, N. Evaluation of the polymer Soluplus® for spray-dried dispersions of poorly soluble compounds, American Association of Pharmaceutical Scientists Annual Meeting, November 2010, Poster AM-10-03815.

Deschamps, J.D., Gautschi, J.T., Whitman, S., Johnson, T.A., Gassner, N.C., Crews, P., Holman, T.R. Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries, Bioorganic & Medicinal Chemistry 2007, 15, 6900-6908.

Gautschi, J.T., Tenney, K., Compton, J., Crews, P. Chemical investigations of a deep water marine-derived fungus: simple amino acid derivatives from an Arthrinium sp., Natural Products Communications 2007, 2, 541-546.

Gautschi, J.T. Ph.D. Thesis: Marine natural products from sponges and deep water, marine-derived fungi, University of California, Santa Cruz: California, June 2006. [Diss. Abstr. Int., B 2006, 67, 2556.]

Flatt, P.M., Gautschi, J.T., Thacker, R.W., Crews, P., Gerwick, W.H.  Localization of dysB1 to the cyanobacterial symbiont Oscillatoria spongeliae in Dysidea (Lamellodysidea) herbacea: analysis of the biosynthetic pathways and production sites for polychlorinated peptides, Marine Biology 2005, 147, 761-774.

Gautschi, J.T., Whitman, S., Holman, T.R., Crews, P. An analysis of phakellin and oroidin structures stimulated by further study of an Agales sponge, Journal of Natural Products 2004, 67, 1256-1261.

Gautschi, J.T., Amagata, T., Amagata, A., Valeriote, F.A., Mooberry, S.L., Crews, P. Expanding the strategies in natural product studies of marine-derived fungi: a chemical investigation of Penicilliumi obtained from deep water sediment,  Journal of Natural Products 2004, 67, 362-367. Erratum J. Nat. Prod. 2004, 67, 1638.

Piña, I.C., Gautschi, J.T., Wang, G.-Y.-S., Sanders, M.L., Schmitz, F.J., France, D., Cornell-Kennon, S., Sambucetti, L.C., Remiszewski, S.W., Perez, L.B., Blair, K.W., Crews, P.  Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase,  Journal of Organic Chemistry 2003, 68, 3866-3873.